Science Out of the Box

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On balance, science tends to follow a slow and incremental path: new observations build on previous findings, often over many years, contributing piecemeal to a larger body of knowledge. But every now and then, insights arise that can dramatically accelerate our understanding of a given subject or take the field in unexpected directions. In this special edition, we've rounded up just these kinds of advances—what Thomas S. Kuhn called “paradigm shifts” in his 1962 book The Structure of Scientific Revolutions.

You'll see in this anthology that revolutionary discoveries can happen in nearly every field. In biology and evolution, researchers have uncovered a remarkable sense of magnetism within birds' eyes that they use to navigate during migrations. Dinosaurs, long thought of and depicted as impressive but drab-looking creatures, in fact weren't drab at all—research on fossilized melanin cells shows that dinosaurs were feathered in bright colors; some even sported dots and stripes. In human history, archaeologists are amending their assumptions about the economic roles that women played in Viking and medieval society, based on recent analyses of North Atlantic textiles.

In cosmology, data from NASA's transformative new observatory—the James Webb Space Telescope—threaten to upend astrophysicists' narrative about how the universe formed, and physicists have devised some astounding ideas about entangled black holes that will help explain an almost century-old paradox. Current views suggest that even our solar system did not establish itself slowly, as was long thought, but was born of a violent blur of impacts and destruction. All of which is confounded by the possibility that what we “see” out in space may not actually be there, in the quantum sense.


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Major advances in our understanding of our own minds and bodies are just as striking. Trauma from events experienced during pregnancy can be passed down to children, evidenced in genetic changes. Evolutionary anthropologist Herman Pontzer and his colleagues have painstakingly gathered surprising information about metabolism and how our bodies burn calories. And the mRNA vaccine technologies developed during the COVID pandemic are poised to revolutionize treatment for a slew of diseases, from herpes simplex virus 2 to norovirus and rabies, to name a few.

One of my graduate school advisers used to say that what humans Know (capital “K”) is infinitesimal compared with what is knowable in the universe. In that spirit, we also present a sample of some of the most fascinating unanswered questions, from the enduring mystery of how human consciousness arises to a growing debate over the very nature of the cosmos.

Some of the most astonishing findings collected here are those where conventional scientific practice went out the window. As lichenologist Toby Spribille tells reporter Erica Gies in “The Meaning of Lichen,” “You have this culture of prepared minds that makes it extremely difficult to think outside the box. It creates the box.” Indeed, the beauty of scientific inquiry is that when we quickly leapfrog the pace of discovery—or take our explorations in totally novel directions—we uncover an entirely new way of thinking. Here's to breaking the box.

Andrea Gawrylewski is chief newsletter editor at Scientific American. She writes the daily Today in Science newsletter and oversees all other newsletters at the magazine. In addition, she manages all special editions and in the past was the editor for Scientific American Mind, Scientific American Space & Physics and Scientific American Health & Medicine. Gawrylewski got her start in journalism at the Scientist magazine, where she was a features writer and editor for "hot" research papers in the life sciences. She spent more than six years in educational publishing, editing books for higher education in biology, environmental science and nutrition. She holds a master's degree in earth science and a master's degree in journalism, both from Columbia University, home of the Pulitzer Prize.

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SA Special Editions Vol 32 Issue 1sThis article was originally published with the title “Science Out of the Box” in SA Special Editions Vol. 32 No. 1s (), p. 1
doi:10.1038/scientificamericanrevoluationary0323-1